Raivo Kolde - DNA Methylation Patterns

Klipi teostus: Mirjam Paales 19.09.2012 12996 vaatamist Arvutiteadus

It has been shown that genetic information is only partially encoded as the order of base-pairs in the DNA. Various DNA packing and modification mechanisms play an important role, as well. In the context of this project, I am interested in DNA methylation. The regulation of methylation of CpG sites is usually not site specific, but rather works on longer genomic regions. However, until now the arrays to measure methylation have been too sparse to determine accurately the genomic regions where methylation is regulated similarly. But now we have several datasets on the new hight density methylation arrays where for many genes we have tens of methylation probes. This allows finding regions that are consistently either up- or down-methylated or that display tissue/condition specific methylation patterns.